Depression arises from a lack of self-appreciation and an inability to move on from painful ruminations.
Gelek Rimpoche gives a variety of suggestions to help free us from the paralysis of depression. Concentrated and analytical meditation can help re-train the mind toward a more objective and confident experience of emotional life.
He gives his views on the value of whatever helps an individual (such as medication) to both ground a person and free energy bound in a depressive mind/body.